Original article

Risk factors and prognostic impact of serious immune-related adverse events induced by nivolumab plus ipilimumab combination therapy in patients with non-small cell lung cancer

WCRJ 2026; 13 : e3001
DOI: 10.32113/wcrj_20262_3001

  Topic: Lung cancer     Category:

Tatsumi A.
Department of Pharmacy, Osaka International Cancer Institute, Osaka Prefectural Hospital Organization, Otemae, Chuo-ku, Osaka-shi, Osaka, Japan
tatsumi@pharm.kobegakuin.ac.jp Close
, Nozawa K.
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Chuo-ku, Kobe, Japan Close
, Funatomi K.
Faculty of Pharmaceutical Sciences,, Kobe Gakuin University, Chuo-ku, Kobe, Japan Close
, Kadokawa Y.
Department of Pharmacy, Osaka International Cancer Institute, Osaka Prefectural Hospital Organization, Otemae, Chuo-ku, Osaka-shi, Osaka, Japan Close
, Hasegawa S.
Department of Pharmacy, Osaka International Cancer Institute, Osaka Prefectural Hospital Organization, Otemae, Chuo-ku, Osaka-shi, Osaka, Japan Close
, Takeda K.
Department of Pharmacy, Osaka International Cancer Institute, Osaka Prefectural Hospital Organization, Otemae, Chuo-ku, Osaka-shi, Osaka, Japan Close
, Takagi M.
Department of Pharmacy, Osaka International Cancer Institute, Osaka Prefectural Hospital Organization, Otemae, Chuo-ku, Osaka-shi, Osaka, Japan Close
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AKR7A2 promotes hepatocellular carcinoma progression through affecting tumor associated macrophage polarization and oxidative phosphorylation

WCRJ 2025; 12 : e2975
DOI: 10.32113/wcrj_202512_2975

  Topic: Hepatocellular Carcinoma     Category:

Cui H.
Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China Close
, Long Q. Q.
Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China Close
, Zhang L.
Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China Close
, Tian H.
Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
htian@shsci.org Close
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Clinical outcomes and prognostic features of germline BRCA mutant breast cancer patients: single-center experience, Madinah, Saudi Arabia

WCRJ 2025; 12 : e2954
DOI: 10.32113/wcrj_202511_2954

  Topic: Breast cancer     Category:

Aljahel M.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Alfotih S.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Fallatah E.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Amine Sekkel M.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Alharbi O.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Alshehri A. A.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Jastaniah Z.
Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, King Abdul Aziz University, Jeddah, Saudi Arabia Close
, Ahmed T.
Radiotherapy and Radiation Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Mulla N.
College of Medicine, Department of Internal Medicine, Taibah University, Tayba, Madinah, Saudi Arabia Close
, Alkhayat D.
Department of Internal Medicine, Taibah University,, Tayba, Madinah, Saudi Arabia Close
, Elbaiomy M. A.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia
malibasha1@mans.edu.eg Close
, Albondagji B.
University Medical Center, Taibah University, Tayba, Madinah, Saudi Arabia Close
, Ghazi H.
Obstetrics and Gynaecology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Khoja M. M. K.
King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia, Close
, Abdelsalam S. A.
Public Health and Community Medicine Department, Faculty of Medicine, Mansoura University, Gehan Al Sadat, Mit Khamis WA Kafr Al Mougi, El Mansoura 1, Egypt Close
, Alghamdi K. S.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
, Abokhalaf E. M.
Medical Oncology Department, King Salman Bin Abdulaziz Medical City (KSAMC), Al Madinah Al Munawwarah, Saudi Arabia Close
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Diagnostic value of contrast-enhanced T2-weighted flair with fat saturation in leptomeningeal metastasis

WCRJ 2025; 12 : e2952
DOI: 10.32113/wcrj_202511_2952

  Topic: Diagnosis and cancer     Category:

Chao H.
Department of Radiology, Changzhou Cancer Hospital of Soochow University, Changzhou, China Close
, Chen W. W.
Department of Radiology, Changzhou Cancer Hospital of Soochow University, Changzhou, China Close
, Rui H. J.
Department of Radiology, Changzhou Cancer Hospital of Soochow University, Changzhou, China Close
, Xiao T. C.
Department of Radiology, Changzhou Cancer Hospital of Soochow University, Changzhou, China Close
, Zhang J.
Department of Radiology, Changzhou Cancer Hospital of Soochow University, Changzhou, China
zjzj125@163.com Close
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GSDMD and PJVK as therapeutic targets and prognostic biomarkers in breast cancer: insights from the Gasdermin family

WCRJ 2025; 12 : e2933
DOI: 10.32113/wcrj_20259_2933

Exploring the anti-tumor mechanisms of Anthriscus sylvestris using a network pharmacology and molecular docking approach

WCRJ 2025; 12 : e2913
DOI: 10.32113/wcrj_20257_2913

  Topic: Complementary and alternative medicine, Translational research     Category:

Shu J. Z.
Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China Close
, Jiang Y.
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China Close
, Chen H. Z.
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China Close
, Liu F. Y.
Chongqing University of Posts and Telecommunications, Chongqing, China Close
, Huang Y. H.
Chongqing University of Posts and Telecommunications, Chongqing, China Close
, Liang Q. Q.
Chongqing University of Posts and Telecommunications, Chongqing, China Close
, Xie Y. F.
Chongqing University of Posts and Telecommunications, Chongqing, China Close
, Chen Y. Y.
Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
eagle109@126.com Close
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MiR-150-3p enhances the sensitivity of non-small cell lung cancer to cisplatin by down-regulating the expression of AKT2

WCRJ 2025; 12 : e2911
DOI: 10.32113/wcrj_20257_2911

  Topic: Lung cancer     Category:

Liu S. L.
Department of Clinical Laboratory, Hunan Provincial People's Hospital and the First-affiliated Hospital of Hunan Normal University, Changsha, Hunan, China
liusile@hunnu.edu.cn Close
, Tan K.
Department of Clinical Laboratory, Hunan Provincial People's Hospital and the First-affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Close
, Zhou Y.
Department of Pathology, Hunan Provincial People's Hospital and the First-Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Close
, Lu X.
Department of Clinical Laboratory, Hunan Provincial People's Hospital and the First-affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Close
, Fu F.
Department of Pathology, Hunan Provincial People's Hospital and the First-Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Close
, Dai P.
Department of Clinical Laboratory, Hunan Provincial People's Hospital and the First-affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Close
, Chen J.
Department of Clinical Laboratory, Hunan Provincial People's Hospital and the First-affiliated Hospital of Hunan Normal University, Changsha, Hunan, China
chenjian9240@126.com Close
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Loss of SETD2 impairs tight junctions and promotes the tumorigenesis of gastric cancer

WCRJ 2025; 12 : e2874
DOI: 10.32113/wcrj_20255_2874

  Topic: Gastrointestinal cancer     Category:

Zhao H. S.
Gastroenterology Department, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang, China Close
, Zhakeer M.
Gastroenterology Department, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang, China Close
, Meng Q. Z.
Gastroenterology Department, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang, China Close
, Qu Y. L.
Gastroenterology Department, Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang, China
quyanli73@163.com Close
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Regulation of Mucin 1 and multidrug resistance protein 1 by Neuraminidase 1 alters the cytotoxic effects of doxorubicin in breast cancer cells

WCRJ 2025; 12 : e2872
DOI: 10.32113/wcrj_20255_2872

The vital role of TRPM2 in breast cancer cell proliferation and its difference in expression between non-Hispanic white and non-Hispanic black females

WCRJ 2025; 12 : e2870
DOI: 10.32113/wcrj_20255_2870

  Topic: Breast cancer     Category:

Huang L. P.
Immunology & Transplant Science Center, Houston Methodist Research Institute, Houston, TX, USA Close
, Lu Y.
Center for Aging, School of Medicine, Tulane University, New Orleans, LA, USA Close
, Li M.
Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA, USA
mli@tulane.edu Close
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