MYC is a potent oncogene and its activation is frequently due by direct gene alteration, such as traslocation and amplification.Originally MYC chromosome translocation t(8;14)(q24;q32) has been considered an hallmark of of Burkitt lymphoma, but later it have been identified in other mature B-cell neoplasms. Detection of translocations involving MYC at 8q24.1 in aggressive B-cell lymphomas is important for diagnostic and prognostic purposes. Therefore, we analyze the genetic aberrations could be applied to a useful Fluorescent In Situ Hybridization (FISH) approach in the diagnosis of these lymphomas.
To cite this article
Detection of MYC rearranged by fluorescence in situ hybridization FISH: a diagnostic tool
WCRJ 2014; 1 (4): e362
Published online: 19 Dec 2014