Background: Recently, Calreticulin (CALR) has been proposed to participate in various physiological and pathological processes in cells. The two major functions of CALR inside the Endoplasmic Reticulum (ER) are protein chaperoning and regulation of Ca++ homeostasis. Furthermore, accumulated studies indicate that CALR also regulates important biological functions including cell adhesion, gene expression, and RNA stability.
Upgrading: This review aims to highlight the most biological function of CALR protein in cancer development. In addition, a comprehensive evaluation of the detection method for revelation of low amount of mutant DNA in a large excess of wild type (wt) DNA is proposed and discussed.
Conclusions: Acknowledgments about CALR function in oncology field will allow the design of new research project that will get light to relationship between normal physiological function and tumors development mediated by CALR. Based on these fields, in the next future, the oncologists will have new markers to strike a precise diagnosis.