Endometriosis is a common gynecological disease which affects different aspects of women’s life in reproductive ages. The objective of this meta-analysis was to investigate the effect of endometriosis on the affected patients’ quality of life (QoL). PubMed, Medline, Embase, Science direct, CINAHL, Cochrane Clinical Trials, Magiran and SID were searched up to November, 19, 2016. The studies using Endometriosis Health Profile-30 (EHP-30) to evaluate QoL in women with endometriosis were selected. A total of 7 studies (1619 cases) which satisfied the inclusion criteria were included in the meta-analysis. The QoL scores in the 5 dimensions of core questionnaire were ranged from 43.70 to 56.14 and in 6 dimensions of the optional modular questionnaire from 30.27 to 59.26. These results confirmed that the endometriosis imposes a considerable burden of QoL on the affected women.