Objective: This study aims to characterize the types of breast cancer among women in Riyadh and evaluate the association between breast cancer types, breast tissue density, and age.

Patients and Methods: This cross-sectional study included 524 female cancer patients aged 18 years with histologically or radiologically confirmed diagnoses from 2012 to 2020. Age, breast density, cancer type, TNM staging, radiographic grade, presence or absence of calcification, histological grading, and surgery type were extracted from the cancer program’s electronic reporting system.

Results: We observed a significant association between type of cancer and age (p=0.006), stage of cancer (p<0.0001), histologic grade (p=0.004), and presence of calcifications (p=0.000). While the younger patients aged <50 had heterogeneously dense breasts, scattered areas of fibro glandular density were common among older patients (p=0.004). Multinomial logistic regression analysis showed that the odds of patients having ductal carcinoma were 11 times higher in patients with Grade I cancer (p=0.011) and three times higher in those with Grade II cancer (p=0.021). The absence of calcifications decreased the odds of ductal carcinoma in situ (p=0.000).

Conclusions: We observed a significant relationship between breast cancer type with age and stage of cancer. Although breast density was associated with age, it was independent of cancer type.