Objective: World Cancer Day (WCD) observed annually every 4^th February has become a rallying point to create awareness and galvanise action globally to fight cancer. This paper describes the activities carried out in the oil-rich Bayelsa State of Nigeria to commemorate WCD 2021.

Materials and Methods: Two non-governmental bodies collaborated to organise a series of campaign activities. These included health talks in clinics and on air, and a road walk that enjoyed the participation of other stakeholders in cancer control in the state.

Results: Health talks and screening for the leading cancers were carried out in clinics and religious houses in all the eight districts of the state. Radio and television stations hosted talks on cancer prevention and control and over a hundred persons participated in the road walk. A large audience was reached with key messages of the day through the different media deployed for the campaign.

Conclusions: WCD 2021 was able to sensitise residents of Bayelsa State to the growing burden of cancer and stimulated them to action. With sustained effort and commitment of all stakeholders, the state may soon have a well-established Cancer Control Programme and set the pace for other states in Nigeria.