Retrospective analysis of the predictors of outcome following local excision for T1 rectal adenocarcinoma
WCRJ 2021;
8
: e2094
DOI: 10.32113/wcrj_20219_2094
Topic: Gastrointestinal cancer
Category: Original article
Abstract
Objective: Early-stage cancers may allow for less radical approaches such as local excision which preserve quality of life without compromising oncologic outcomes. We examined outcomes of patients with early-stage rectal adenocarcinoma treated with Local excision (LE).
Patients and Methods: We queried the NCDB for patients with pT1N0M0 rectal adenocarcinoma treated with local excision alone. Multivariable Cox regression was used to identify predictors of overall survival (OS).
Results: We identified 887 patients eligible for analysis across 2010-2014. The median tumor size was 1.5 cm (IQ range: 0.9-2.5 cm). A minority of patients had grade 3 tumors (5%), lymphovascular invasion - LVI (8%), or perineural invasion PNI (<1%). Median follow up was 36 months (1-83). Predictors of worse survival included: size >4 cm, age >67, higher comorbidity score, and presence of LVI. On Kaplan Meier analysis, 5-year OS was 75% vs. 74% for patients without and with LVI, respectively (p-value=0.0115). In terms of size, the 5-year OS rates were 74% for size <4 cm vs. 51% size >4 cm (p-value=0.0138).
Conclusions: The study demonstrates excellent survival outcomes in patients with early-stage rectal adenocarcinoma treated with LE alone. LVI remains a predictor of outcome, while grade and PNI were not significant.
Patients and Methods: We queried the NCDB for patients with pT1N0M0 rectal adenocarcinoma treated with local excision alone. Multivariable Cox regression was used to identify predictors of overall survival (OS).
Results: We identified 887 patients eligible for analysis across 2010-2014. The median tumor size was 1.5 cm (IQ range: 0.9-2.5 cm). A minority of patients had grade 3 tumors (5%), lymphovascular invasion - LVI (8%), or perineural invasion PNI (<1%). Median follow up was 36 months (1-83). Predictors of worse survival included: size >4 cm, age >67, higher comorbidity score, and presence of LVI. On Kaplan Meier analysis, 5-year OS was 75% vs. 74% for patients without and with LVI, respectively (p-value=0.0115). In terms of size, the 5-year OS rates were 74% for size <4 cm vs. 51% size >4 cm (p-value=0.0138).
Conclusions: The study demonstrates excellent survival outcomes in patients with early-stage rectal adenocarcinoma treated with LE alone. LVI remains a predictor of outcome, while grade and PNI were not significant.
To cite this article
Retrospective analysis of the predictors of outcome following local excision for T1 rectal adenocarcinoma
WCRJ 2021;
8
: e2094
DOI: 10.32113/wcrj_20219_2094
Publication History
Submission date: 28 Jul 2021
Revised on: 06 Sep 2021
Accepted on: 23 Sep 2021
Published online: 29 Sep 2021

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