Objective: Non-Hodgkin’s Lymphoma (NHL) with a cancer burden of 3% is one of the most commonly reported malignancies worldwide. The present study aims to investigate the epidemiology and risk factors of this cancer in the world.

Patients and Methods: This study was conducted on published English studies by 2018 by searching in the databases of PubMed, Google Scholar and Web of Science. The search strategy included the keywords “Non-Hodgkin’s Lymphoma”, “Epidemiology,” “Incidence”, “Mortality”, “Risk factors”. Studies related to incidence, mortality, and causes of NHL were evaluated.

Results: The highest incidence rates of this malignancy were observed in North America, Australia and Europe, and the lowest ones were in Asia and the Pacific. At the same time, some studies reported that mortality rates increase in some areas. Based on previous studies, 1 out of 110 men and 1 of 161 women suffer from NHL during their life. Also, factors such as lifestyle, age and gender, occupational conditions and environmental factors, infectious agents, genetics and family history, and autoimmune diseases play an important role in the incidence of this disease.

Conclusions: The incidence and death rate of NHL are different in various regions. So that, the studies which show the incidence of this disease and better identification of the related factors, which are associated with these differences, can be useful.