HER2 expression in gastrointestinal tumor. A focus on diagnostic algorithm of HER2 status from gastric to intestinal cancer

WCRJ 2019; 6: e1230
DOI: 10.32113/wcrj_20193_1230

  Topic: Cancer and diagnosis     Category:

Abstract

Human epidermal growth factor receptor 2 (HER2) is a transmembrane growth factor receptor with tyrosine kinase activity regulating cell growth and survival. HER2 amplification is responsible for protein overexpression with a negative impact on prognosis, but HER2-overexpressing patients could be treated with anti-HER2 therapy. In gastric cancer HER2 overexpression is observed in approximately 22% of patients, but prognostic significance in this context is not clear. In colon adenocarcinoma, HER2 gene amplification is reported in a wide range from 0% to 83%. The wide range of reported series could be essentially attributable to a difference in scoring systems for HER2 protein expression. The use of testing score, although measuring the same protein, is different from gastric cancer to colorectal cancer. Herein the different scoring models are reported.

To cite this article

HER2 expression in gastrointestinal tumor. A focus on diagnostic algorithm of HER2 status from gastric to intestinal cancer

WCRJ 2019; 6: e1230
DOI: 10.32113/wcrj_20193_1230

Publication History

Submission date: 29 Nov 2018

Revised on: 10 Dec 2018

Accepted on: 13 Dec 2018

Published online: 11 Mar 2019