Objective: Colorectal cancer (CRC) is a common and lethal disease and is one of the most common cancers worldwide. This study attempted to statistically analyze the epidemiological characteristics rate of colorectal cancer patients admitted to a Referral Center, Northern Iran from 2006 to 2015.

Patients and Methods: This was a descriptive-analytical, cross-sectional and retrospective study. The patients’ information and relevant variables were recorded. Data were analyzed through descriptive, in SPSS.

Results: The highest incidence was observed in patients over 60 years of age and it was more common in men than women. In terms of grading, the highest frequency was found in well differentiation, while the lowest frequency was found in poor differentiation. Most of the patients fell under IIA and IIIB staging and the most frequent type of invasion was regional. The most frequent involvement was found in rectum and rectosigmoid, and the involvement distance to anal verge in the majority of patients was more than 8 cm. The CEA Index in the majority of patients ranged from 2.5 to 20 ng/ml. Results also display the positive trends in cancer records, grading, gender segregation and age groups, respectively.

Conclusions: The highest prevalence of colorectal cancer belonged to men patients over 60 years, in rectum, with regional well differentiation and younger age are affected by colorectal cancer in the region. This certainly calls for further attention to preventive planning and training on cancer in developing health policies.