Clinically relevant of Cytochrome P450 Family enzymes for drug-drug interaction in anticancer therapy

WCRJ 2015; 2 (2): e524

  Topic: Pharmacology     Category:

Abstract

In the oncology field, the knowledge of secondary mechanisms for drug metabolism allow physicians to improve the efficacy of cancer therapy.

This review provides an overview on the commonly occurring, functionally and/or clinically relevant Cytochrome P450 (CYP) superfamily. Particular highlight were attempt on genetic variations in the CYP2D6 gene and the pharmacokinetics and/or response of drug-based chemotherapy. In addition, current genetic polymorphisms responsible of variability in drug-drug interaction between anticancer drugs and antidepressant are discussed.

Further, effective re-evaluation of drug design based on CYP enzymes profile may eventually be personalized and individualized to the patient for maximum efficacy of the therapies.

To cite this article

Clinically relevant of Cytochrome P450 Family enzymes for drug-drug interaction in anticancer therapy

WCRJ 2015; 2 (2): e524

Publication History

Published online: 30 Jun 2015