Silver nanoparticles inhibit proliferation and migration of prostate cancer cells: an experimental report

WCRJ 2022; 9: e2242
DOI: 10.32113/wcrj_20223_2242

  Topic: Genitourinary cancer     Category:

Abstract

Objective: Prostate carcinoma is a serious public health in men with increasing incidence and mortality rates. The present study aimed to investigate cytotoxic activities of silver nanoparticles (AgNPs) against PC-3 human prostate cancer cell line in vitro.

Materials and Methods: The antiproliferative effect of AgNPs on PC-3 cells was assessed using various concentrations of AgNPs (5-80 µg/mL) by MTT assay. We have also investigated the effect of AgNPs on the migration property of cancers cells using a wound-healing assay. Then, obtained results were analyzed using ANOVA and Student’s t-test.

Results: The AgNPs diminished significantly the viability of PC-3 cells in a dose and time-dependent manner. According to the dose-dependent viability curve, the IC50 (50% inhibiting concentration) at 48 h was calculated to be 65.7 µg/mL. Migration assay also confirmed the antimetastatic potential of the AgNPs against PC-3 cells. After 24 h, the migration rate was 2.5 fold lower for AgNPs-treated cells compared to control cells.

Conclusions: Our findings support the use of AgNPs as an appropriate option for future therapeutic application in prostate cancer therapy.

To cite this article

Silver nanoparticles inhibit proliferation and migration of prostate cancer cells: an experimental report

WCRJ 2022; 9: e2242
DOI: 10.32113/wcrj_20223_2242

Publication History

Submission date: 04 Oct 2021

Revised on: 11 Nov 2021

Accepted on: 16 Feb 2022

Published online: 17 Mar 2022