Letter to the Editor-MYC deregulation in B-cell cutaneous lymphomas

WCRJ 2020; 7: e1636
DOI: 10.32113/wcrj_20207_1636

  Topic: Molecular diagnosis     Category:

Cutaneous lymphomas are a heterogeneous group of malignant neoplasms constituted by lymphoid cells, originating primarily in the skin. Most cutaneous lymphomas are T-cell neoplasms, while B-cell lymphomas are rare1. Some primarily cutaneous B-cell lymphomas with specific clinical, biological and molecular features are defined and include primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle-center cell lymphoma (PCFCL), and diffuse large B-cell lymphoma, leg type (PCDLBCL, LT)2. Nevertheless, other B-cell neoplasms may primarily originate in the skin, including diffuse large B-cell lymphoma (DLBCL), B-cell lymphoblastic lymphoma and others3,4. Although the exact pathogenesis of cutaneous neoplasms is not fully understood, some molecular alterations have been defined for prognostic and predictive purposes5. Among these, MYC deregulation seem to play an important role in a significant percentage of B-cell cutaneous lymphoma, as well as already known for nodal lymphomas and other solid tumors6. Indeed, MYC alterations seem to be particularly frequent in DLBCL and PCDLBCL, LT. In particular, a rearrangement of MYC gene has been reported in up to 43% of PCDLBCL, LT, more often in absence of concomitant BCL2 and BCL6 translocations7. On the other hand, the report of MYC alterations in PCFCL and PCMZL was anecdotal.  Notably, both MYC gene rearrangements and myc protein overexpression are associated with a poor outcome in cutaneous lymphomas7. MYC functions as a master transcriptional regulator with direct or indirect effects on almost all the cellular activities, including apoptosis, replication, differentiation and cell cycle regulation. Although translocation is the best characterized MYC molecular alteration in lymphomas, there are other complex and only partially known molecular mechanisms leading MYC deregulation. In particular, the post-transcriptional and epigenetic regulations have recently emerged as important mechanisms. The better characterization of MYC deregulation in cutaneous lymphomas may open the door to future targeted therapy, mainly in aggressive cases.

Conflict of Interest: The Authors declare that they have no conflict of interests.


  1. Sica A, Vitiello P, Sorriento A, Ronchi A, Calogero A, Sagnelli C, Troiani T, Fasano M, Dodaro CA, Franco R, Casale B, Santangelo M, Ciccozzi M, Ciardiello F, Argenziano G, Moscarella E. Lymphomatoid papulosis. Minerva Med 2020; 111: 166-172.

2.Vitiello P, Sica A, Ronchi A, Caccavale S, Franco R, Argenziano G. Primary cutaneous B-cell lymphomas: an update. Front Oncol 2020; 10: 651.

  1. Sica A, Vitiello P, Caccavale S, Sagnelli C, Calogero A, Doraro CA, Pastore F, Ciardiello F, Argenziano G, Reginelli A, Cappabianca S, Franco R, Ronchi A. Primary cutaneous DLBCL non-GCB type: challenges of a rare case. Open Med (Wars) 2020; 15: 119-125.
  2. Ronchi A, Zito Marino F, Vitiello P, Caccavale S, Argenziano G, Crisci S, Franco R, Sica A. A case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse large B-cell lymphoma with immature features or B-cell lymphoblastic lymphoma? J Cutan Pathol 2020 Jul 4.
  3. Franco R, Nicoletti G, Lombardi A, Di Domenico M, Botti G, Zito Marino F, Caraglia M. Current treatment of cutaneous squamous cancer and molecular strategies for its sensitization to new target-based drugs. Expert Opin Biol Ther 2013; 13: 51-66.
  4. Zito Marino F, Bianco R, Accardo M, Ronchi A, Cozzolino I, Morgillo F, Rossi G, Franco R. Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implications. Int J Med Sci 2019; 16: 981-989.
  5. Schrader AMR, Jansen PM, Vermeer MH, Kleiverda JK, Vermaat JSP, Willemze R. High Incidence and Clinical Significance of MYC Rearrangements in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. Am J Surg Pathol 2018; 42: 1488-1494.

To cite this article

Letter to the Editor-MYC deregulation in B-cell cutaneous lymphomas

WCRJ 2020; 7: e1636
DOI: 10.32113/wcrj_20207_1636

Publication History

Submission date: 02 Jul 2020

Revised on: 06 Jul 2020

Accepted on: 10 Jul 2020

Published online: 16 Jul 2020