– People living with HIV nowadays have an average life-length similar to the general population and new pathologies, such as lung cancer, emerged. The likelihood of developing lung cancer in HIV-infected people is related to the increase of the mean age, male sex, smoke, persistent lung inflammation, and new studies are being conducted to find new soluble markers which could lead to an early diagnosis of lung cancer. Moreover, treatment opportunities are being enriched with new biological medicine, even though further studies are needed to determine if their use is safe in people living with HIV. The aim of this review is to identify key data and factors about lung cancer in HIV-infected patients.