Carcinogenic and therapeutic role of High-Mobility Group Box 1 in Cancer: is it a cancer facilitator, a cancer inhibitor or both?

WCRJ 2017; 4 (3): e919

  Topic: Translational research     Category:

Abstract

High-mobility group box 1 protein (HMGB1), one of the best described damage-associated molecular patterns (DAMP), is a chromatin concomitant nuclear protein. Inside the nucleus, HMGB1 acts as a formational chromatin-binding factor and facilitates the congregation of proteins such as p53, p73, Rel/NF-kB, estrogen receptor etc. on explicit DNA foci. Extracellularly, HMGB1 via the interaction with receptors such as receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs), to facilitate numerous biological functions like inflammation, cell migration, cell differentiation and cancer metastasis. Current studies have implicated HMGB1 as a key regulator protein in the pathogenesis as well as therapeutic potentials in cancer. The signaling mechanism via which HMGB1 advances clinicopathologically is also reconnoitered; however, advance studies are still desirable in some cancers. The mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1 mainly focus on biochemistry, molecular biology, and clinicopathology. Our review focuses on the clinicopathological and therapeutic role of HMGB1 in cancers.

To cite this article

Carcinogenic and therapeutic role of High-Mobility Group Box 1 in Cancer: is it a cancer facilitator, a cancer inhibitor or both?

WCRJ 2017; 4 (3): e919

Publication History

Submission date: 06 Sep 2017

Revised on: 12 Sep 2017

Accepted on: 25 Sep 2017

Published online: 29 Sep 2017